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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Luis Martínez# | 2.270 | 1906-1909 | |
| 2 | Gabriel Morales# | 2.296 | 1906-1911 | |
| 3 | Timoteo Muriel# | 2.397 | 1905-1913 | |
| 4 | Darío Centeno# | 2.432 | 1902-1915 | |
| 5 | Víctor Andreu# | 2.482 | 1901-1915 | |
| 6 | Rhys Wilson | 2.497 | 1906-1914 | |
| 7 | Javier Cortez# | 2.521 | 1906-1909 | |
| 8 | Pedro Ayala# | 2.535 | 1906-1915 | |
| 9 | Diego Bedolla# | 2.556 | 1905-1909 | |
| 10 | Eduardo Campoverde# | 2.587 | 1906-1915 | |
| 11 | Felipe Ramos# | 2.622 | 1906-1913 | |
| 12 | Narciso Vega# | 2.704 | 1906-1915 | |
| 13 | Eugenio Pérez# | 2.725 | 1906-1911 | |
| 14 | Tácito Gudino# | 2.731 | 1906-1915 | |
| 15 | Alberto Ponce# | 2.739 | 1906-1912 | |
| 16 | Felipe García | 2.771 | 1903-1913 | |
| 17 | Labán Hernández# | 2.786 | 1906-1909 | |
| 18 | Miguel Vásquez# | 2.831 | 1906-1907 | |
| 19 | Rodrigo Heredia | 2.832 | 1903-1906 | |
| 20 | Marc Stabb | 2.837 | 1910-1915 | |
| 21 | Weston Bourgeois | 2.842 | 1906-1914 | |
| 22 | Efraín Rosell | 2.906 | 1903-1911 | |
| 23 | Lorenzo Cabrera | 2.916 | 1901-1911 | |
| 24 | Noé González | 2.933 | 1901-1911 | |
| 25 | Miguel Díaz | 2.935 | 1904-1906 | |
| 26 | Joaquín Espinosa | 2.962 | 1901-1906 | |
| 27 | Ulises Ramírez | 2.978 | 1901-1911 | |
| 28 | Matías Martínez# | 2.997 | 1905-1915 | |
| 29 | Bonifacio Martínez# | 3.001 | 1911-1915 | |
| 30 | Pablo Villada | 3.013 | 1902-1913 | |
| 31 | Oscar Soto | 3.019 | 1903-1913 | |
| 32 | Íñigo León# | 3.036 | 1902-1915 | |
| 33 | Herminio Vargas# | 3.045 | 1906-1910 | |
| 34 | Søren Fetterlein# | 3.049 | 1912-1914 | |
| 35 | Adrián Acosta | 3.051 | 1901-1909 | |
| 36 | Luis Valentín# | 3.059 | 1912-1915 | |
| 37 | Marcos Guevara | 3.079 | 1903-1912 | |
| 38 | Santiago Ayala# | 3.080 | 1906-1914 | |
| 39 | Próspero López# | 3.081 | 1910-1915 | |
| 40 | Mateo Lugo | 3.084 | 1901-1907 | |
| 40 | Imrich Tosenovsky# | 3.084 | 1913-1915 | |
| 42 | Carlos Guzmán | 3.086 | 1901-1906 | |
| 43 | Gelasio Campos# | 3.095 | 1906-1912 | |
| 44 | Reginaldo Cervantes | 3.099 | 1901-1912 | |
| 45 | Francisco García# | 3.143 | 1905-1913 | |
| 46 | Loquillo Martínez | 3.172 | 1901-1914 | |
| 46 | Nicandro González# | 3.172 | 1903-1914 | |
| 48 | José Cisneros# | 3.183 | 1902-1913 | |
| 49 | Carmelo Contreras# | 3.184 | 1911-1914 | |
| 50 | Jesús Escobales | 3.188 | 1902-1912 | |
| 51 | Dermot Britton | 3.190 | 1913-1915 | |
| 52 | Lope Zepeda# | 3.193 | 1910-1915 | |
| 53 | Diego Navarro# | 3.197 | 1905-1913 | |
| 54 | Bartolomé Carrada | 3.208 | 1903-1911 | |
| 55 | Oliver Huerta | 3.211 | 1901-1906 | |
| 56 | Semónides Cataño# | 3.214 | 1903-1909 | |
| 57 | Prudencio Ulloa# | 3.215 | 1906-1915 | |
| 58 | Matt Tulk | 3.218 | 1901-1908 | |
| 59 | Uranio Hinojosa | 3.237 | 1903-1911 | |
| 60 | Julio Hernández | 3.254 | 1901-1912 | |
| 61 | Inocencio López# | 3.257 | 1903-1914 | |
| 62 | Ross Culp | 3.262 | 1901-1911 | |
| 63 | Radamés Rodríguez | 3.274 | 1901-1911 | |
| 64 | Adrián Jiménez | 3.280 | 1901-1905 | |
| 65 | Manuel Barragán | 3.284 | 1902-1912 | |
| 66 | Oscar Escalante | 3.285 | 1901-1904 | |
| 67 | Pedro Cabadas# | 3.288 | 1911-1913 | |
| 68 | Cornelio Bazán# | 3.294 | 1904-1912 | |
| 68 | Jorge Ruiz | 3.294 | 1901-1910 | |
| 70 | Efraín Castro | 3.296 | 1901-1911 | |
| 71 | Samuel Villalba# | 3.317 | 1906-1909 | |
| 72 | David Cleary | 3.321 | 1901-1906 | |
| 73 | Natalino Parra# | 3.334 | 1909-1914 | |
| 74 | Osvaldo Rosales# | 3.336 | 1903-1913 | |
| 75 | Amadeo Zúñiga# | 3.343 | 1913-1915 | |
| 76 | Marcos Rocha | 3.346 | 1901-1905 | |
| 77 | Salvino Velázquez | 3.368 | 1902-1906 | |
| 78 | Juan Medina# | 3.371 | 1912-1915 | |
| 79 | Jorge Torres | 3.382 | 1901-1911 | |
| 80 | Elián Lara | 3.388 | 1903-1911 | |
| 81 | José Medina | 3.389 | 1901-1905 | |
| 82 | Tung Cao# | 3.392 | 1913-1915 | |
| 83 | Judá García# | 3.394 | 1906-1910 | |
| 84 | Patricio Rodríguez | 3.398 | 1901-1908 | |
| 85 | Raúl González# | 3.400 | 1912-1915 | |
| 86 | Catulo Martínez | 3.401 | 1901-1906 | |
| 87 | Esteban Reyes# | 3.412 | 1906-1910 | |
| 88 | Virgilio Felán | 3.419 | 1901-1910 | |
| 89 | Ginés Valdés | 3.423 | 1901-1909 | |
| 89 | Ramón Pagán | 3.423 | 1902-1913 | |
| 91 | Chae-ho Lee# | 3.428 | 1912-1914 | |
| 92 | Jorge Reyes | 3.429 | 1901-1905 | |
| 93 | Édgar González# | 3.441 | 1910-1913 | |
| 94 | Epifanio Cuenca# | 3.463 | 1903-1915 | |
| 95 | Séptimo Salazar# | 3.464 | 1912-1915 | |
| 96 | Rodolfo Valdés# | 3.465 | 1912-1915 | |
| 97 | Duarte Blanco | 3.466 | 1901-1907 | |
| 98 | Rubén Quiroz# | 3.478 | 1906-1915 | |
| 99 | Stepán Sindelar# | 3.493 | 1910-1915 | |
| 100 | Jesús Sánchez# | 3.494 | 1906-1914 |
