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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | HR | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Plutarco Flores# | 165 | 1905-1911 | |
| 2 | Dagoberto Villanueva# | 103 | 1903-1914 | |
| 3 | Marcelo Antonio# | 69 | 1903-1913 | |
| 4 | Atanasio Parga | 66 | 1901-1911 | |
| 5 | Marco Mora# | 63 | 1905-1915 | |
| 6 | Aramis González | 58 | 1908-1914 | |
| 7 | Teócrito Guillén | 57 | 1903-1913 | |
| 8 | Apolonio Anaya | 54 | 1901-1909 | |
| 9 | Aldo Flores | 49 | 1901-1910 | |
| 10 | Jerónimo Guerra | 47 | 1901-1911 | |
| 10 | Guiomar Segura | 47 | 1902-1912 | |
| 12 | Abenámar Andrade | 46 | 1903-1913 | |
| 12 | Gabriel Sánchez | 46 | 1906-1913 | |
| 14 | Julio García | 44 | 1905-1912 | |
| 15 | Raúl Sánchez | 43 | 1904-1914 | |
| 16 | Germán Coronado | 42 | 1901-1913 | |
| 16 | Filóxenos Ruiz# | 42 | 1904-1915 | |
| 18 | Luis Cárdenas | 41 | 1901-1909 | |
| 19 | Aarón Tapia | 38 | 1903-1913 | |
| 20 | Eladio Gática | 36 | 1901-1908 | |
| 21 | Prudencio Granados# | 34 | 1907-1912 | |
| 22 | John Lesage | 33 | 1913-1915 | |
| 23 | Leonard Bonelli | 31 | 1901-1911 | |
| 24 | Miguel Salazar# | 30 | 1911-1915 | |
| 24 | Sarpedón Ávalos# | 30 | 1911-1914 | |
| 26 | Manuel Cuevas | 28 | 1904-1913 | |
| 26 | Apolonio Gutiérrez# | 28 | 1906-1909 | |
| 28 | Pablo Delgado | 27 | 1911-1915 | |
| 29 | Connor Garner | 26 | 1904-1911 | |
| 29 | Louis Maes# | 26 | 1913-1914 | |
| 29 | Olívio Soromenho# | 26 | 1915-1915 | |
| 32 | Celino Hernández# | 25 | 1912-1913 | |
| 32 | Timoteo López | 25 | 1903-1912 | |
| 32 | Jorge Orduña# | 25 | 1911-1915 | |
| 32 | Nicolás Tapia | 25 | 1906-1912 | |
| 36 | Cedro Miranda | 24 | 1905-1914 | |
| 37 | Rubén Cifuentes# | 23 | 1912-1915 | |
| 37 | John Yates | 23 | 1901-1913 | |
| 39 | Moisés Domínguez | 22 | 1907-1910 | |
| 39 | Rodrigo Jiménez | 22 | 1906-1913 | |
| 39 | Gary Lind | 22 | 1914-1914 | |
| 39 | Oscar Perea | 22 | 1903-1910 | |
| 39 | Jean-Michel Poncet | 22 | 1913-1915 | |
| 39 | Rafael Trujillo | 22 | 1901-1906 | |
| 45 | Luis Cantú | 21 | 1901-1906 | |
| 45 | Miguel Flores | 21 | 1901-1913 | |
| 47 | Rolf Fischer | 19 | 1912-1914 | |
| 47 | Dan Petrescu | 19 | 1915-1915 | |
| 49 | Dara Campbell# | 18 | 1910-1911 | |
| 50 | Sixto Adame | 17 | 1903-1913 | |
| 50 | Sheedy Fitzpatrick# | 17 | 1912-1915 | |
| 50 | Hermógenes López# | 17 | 1913-1914 | |
| 50 | Rainer Steen# | 17 | 1913-1915 | |
| 54 | Mitchell Davies# | 16 | 1913-1915 | |
| 54 | Felipe Estrada | 16 | 1905-1914 | |
| 54 | Mason Gilbert | 16 | 1912-1914 | |
| 54 | Miguel Ángel Hernández | 16 | 1906-1913 | |
| 54 | Serafín Martínez | 16 | 1901-1905 | |
| 54 | Cristón Padilla# | 16 | 1912-1915 | |
| 54 | Diego Ramírez | 16 | 1903-1910 | |
| 54 | Luis Román | 16 | 1901-1906 | |
| 62 | Robbie Knights | 15 | 1914-1915 | |
| 62 | Alfie Marsh | 15 | 1912-1915 | |
| 62 | Kirk Thompson | 15 | 1901-1911 | |
| 62 | Bonifacio Álvarez | 15 | 1910-1912 | |
| 66 | Orestes Durán | 14 | 1910-1913 | |
| 66 | Timón Figueroa | 14 | 1901-1904 | |
| 66 | Ramón García | 14 | 1903-1912 | |
| 66 | Jesús Rodríguez | 14 | 1905-1911 | |
| 70 | Mateo Bueno# | 13 | 1914-1915 | |
| 70 | Crisóstomo Euceda | 13 | 1901-1905 | |
| 70 | Valentín López | 13 | 1903-1912 | |
| 73 | Diógenes Armas# | 12 | 1914-1915 | |
| 73 | Declan Christie | 12 | 1914-1914 | |
| 73 | Elton Creamer# | 12 | 1912-1913 | |
| 73 | Benedicto Estrada# | 12 | 1904-1907 | |
| 73 | Alejandro Gabriel | 12 | 1901-1905 | |
| 73 | Zeferino González# | 12 | 1911-1915 | |
| 73 | Vicente Juárez | 12 | 1906-1912 | |
| 73 | Brendan Lacroix# | 12 | 1913-1915 | |
| 73 | Evaristo Landeros# | 12 | 1912-1915 | |
| 73 | Tirso López | 12 | 1903-1913 | |
| 73 | Bernabé Olague | 12 | 1901-1908 | |
| 73 | Esteban Rueda# | 12 | 1914-1915 | |
| 73 | Joshua Walker | 12 | 1911-1912 | |
| 73 | James Wilson | 12 | 1912-1915 | |
| 87 | Julio Borges | 11 | 1912-1914 | |
| 87 | Luis Cruz# | 11 | 1906-1915 | |
| 87 | Humberto Fujii# | 11 | 1915-1915 | |
| 90 | Da'ud Gamal# | 10 | 1911-1914 | |
| 90 | Aristarco García | 10 | 1901-1904 | |
| 90 | Daniel José | 10 | 1901-1913 | |
| 90 | Dan Leveille | 10 | 1909-1912 | |
| 90 | Heriberto López | 10 | 1901-1909 | |
| 90 | Rufo Olivares# | 10 | 1912-1915 | |
| 90 | Mustafa Pommier | 10 | 1912-1914 | |
| 90 | Ron Riehle | 10 | 1901-1904 | |
| 90 | Sócrates Torres | 10 | 1901-1902 | |
| 90 | Dean Yeates | 10 | 1914-1915 | |
| 90 | Eduardo Álvarez | 10 | 1901-1903 |
