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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Career Leaderboard |
|---|---|---|---|---|
| 1 | Xyzzy Plugh# | 0.000 | 1914 | |
| 2 | Loquillo Martínez | 0.923 | 1901 | |
| 3 | Santiago Romero | 0.982 | 1913 | |
| 4 | Oscar Soto# | 1.019 | 1905 | |
| 5 | Anthony Widdowson# | 1.066 | 1911 | |
| 6 | Joaquín Espinosa | 1.333 | 1905 | |
| 7 | Carlos Caballero | 1.350 | 1904 | |
| 8 | Rosario Negrete# | 1.432 | 1911 | |
| 9 | Efraín Castro | 1.446 | 1902 | |
| 10 | Manuel Barragán | 1.500 | 1904 | |
| 11 | Ramón Pagán | 1.549 | 1911 | |
| 12 | Ross Culp | 1.558 | 1909 | |
| 13 | Gabriel Morales# | 1.588 | 1911 | |
| 13 | Weston Bourgeois | 1.588 | 1911 | |
| 15 | Rafael Martínez# | 1.748 | 1914 | |
| 16 | Oscar Carreno | 1.768 | 1901 | |
| 17 | Ruy Herrera# | 1.800 | 1913 | |
| 17 | Marcos Guevara | 1.800 | 1904 | |
| 17 | Narciso Vega# | 1.800 | 1906 | |
| 20 | Luis Martínez# | 1.831 | 1908 | |
| 21 | Brandon Taylor# | 1.835 | 1914 | |
| 22 | Efraín Castro | 1.855 | 1908 | |
| 23 | Felipe Ramos# | 1.895 | 1907 | |
| 24 | Flavio Inay# | 1.904 | 1911 | |
| 25 | Santiago Ayala# | 1.976 | 1914 | |
| 26 | Darío Centeno# | 1.988 | 1903 | |
| 27 | Gabriel Morales# | 2.000 | 1907 | |
| 27 | Telamón Ávila | 2.000 | 1912 | |
| 27 | Michael Allan# | 2.000 | 1911 | |
| 27 | Darío Centeno# | 2.000 | 1904 | |
| 31 | Florián Sandoval# | 2.032 | 1905 | |
| 32 | Oscar Escalante | 2.045 | 1902 | |
| 33 | Latif bin Afif# | 2.077 | 1913 | |
| 34 | Octavio Álvarez# | 2.093 | 1905 | |
| 35 | Noé González | 2.118 | 1901 | |
| 36 | Pablo Villada | 2.132 | 1902 | |
| 37 | Gabriel Morales# | 2.216 | 1910 | |
| 38 | Felipe García | 2.288 | 1906 | |
| 39 | Telamón Ávila | 2.298 | 1913 | |
| 40 | Oscar Soto# | 2.305 | 1908 | |
| 41 | Samuel Villalba# | 2.328 | 1909 | |
| 42 | Jesús Sánchez# | 2.337 | 1912 | |
| 43 | Egidio Rodríguez# | 2.339 | 1903 | |
| 44 | Ramón Pagán | 2.348 | 1913 | |
| 45 | Florián Sandoval# | 2.382 | 1906 | |
| 46 | Julio Hernández | 2.423 | 1902 | |
| 47 | Oscar Soto# | 2.455 | 1906 | |
| 48 | Rhys Wilson | 2.473 | 1909 | |
| 49 | Timoteo Muriel# | 2.481 | 1912 | |
| 50 | José Cisneros# | 2.483 | 1912 | |
| 51 | Marcos Guevara | 2.487 | 1908 | |
| 52 | Egidio Rodríguez# | 2.500 | 1902 | |
| 52 | Pablo Villada | 2.500 | 1912 | |
| 54 | Matías Martínez# | 2.508 | 1913 | |
| 55 | Lorenzo Cabrera | 2.526 | 1908 | |
| 56 | Adrián Acosta | 2.547 | 1901 | |
| 56 | Rufo Porrata# | 2.547 | 1914 | |
| 56 | Timoteo Muriel# | 2.547 | 1907 | |
| 59 | Francisco García# | 2.562 | 1906 | |
| 60 | Francisco García# | 2.571 | 1905 | |
| 61 | Oscar Soto# | 2.593 | 1911 | |
| 62 | Faustino Garza | 2.596 | 1901 | |
| 63 | Crisóstomo Yáñez# | 2.630 | 1913 | |
| 64 | Noé González | 2.634 | 1907 | |
| 65 | Florián Sandoval# | 2.647 | 1908 | |
| 66 | Octavio Álvarez# | 2.656 | 1902 | |
| 67 | Ross Culp | 2.659 | 1904 | |
| 68 | Matías Martínez# | 2.700 | 1908 | |
| 68 | Loquillo Martínez | 2.700 | 1902 | |
| 68 | Stewart Thomas# | 2.700 | 1913 | |
| 68 | Bonifacio Martínez# | 2.700 | 1913 | |
| 68 | Nathan Lloyd# | 2.700 | 1913 | |
| 73 | Catulo Martínez | 2.717 | 1901 | |
| 74 | Javier Cortez# | 2.755 | 1909 | |
| 75 | Osvaldo Rosales# | 2.769 | 1912 | |
| 76 | Teófilo Espinal# | 2.784 | 1913 | |
| 77 | Adrián Jiménez | 2.872 | 1902 | |
| 78 | Epifanio Cuenca# | 2.876 | 1913 | |
| 79 | Acacio Tejada | 2.880 | 1903 | |
| 79 | Rhys Wilson | 2.880 | 1908 | |
| 81 | Osvaldo Rosales# | 2.893 | 1904 | |
| 82 | Símaco Montes | 2.919 | 1901 | |
| 83 | Felipe Ramos# | 2.935 | 1912 | |
| 84 | Darío Centeno# | 2.945 | 1905 | |
| 84 | Diego Bedolla# | 2.945 | 1906 | |
| 86 | Alberto Nava | 3.000 | 1901 | |
| 86 | Labán Hernández# | 3.000 | 1906 | |
| 86 | Valentín Ramírez# | 3.000 | 1911 | |
| 86 | Noé González | 3.000 | 1908 | |
| 86 | Felipe Ramos# | 3.000 | 1908 | |
| 91 | Robert Troy | 3.042 | 1912 | |
| 92 | Vicente Valdez | 3.062 | 1901 | |
| 93 | Judá García# | 3.076 | 1907 | |
| 94 | Ramón Pagán | 3.115 | 1906 | |
| 94 | Felipe García | 3.115 | 1907 | |
| 94 | Pablo Villada | 3.115 | 1905 | |
| 97 | Joaquín Espinosa | 3.126 | 1903 | |
| 98 | Édgar González# | 3.135 | 1911 | |
| 99 | Séptimo Salazar# | 3.176 | 1914 | |
| 100 | Weston Bourgeois | 3.188 | 1907 |
