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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Postseason Leaderboard |
|---|---|---|---|---|
| 1 | Anthony Widdowson | 1.392 | 1909-1915 | |
| 2 | Rosario Negrete# | 1.432 | 1911-1914 | |
| 3 | Carmelo González# | 1.575 | 1906-1912 | |
| 4 | Brandon Taylor | 1.835 | 1912-1915 | |
| 5 | Loquillo Martínez | 1.881 | 1901-1914 | |
| 6 | Flavio Inay# | 1.904 | 1910-1912 | |
| 7 | Oscar Carreno | 1.983 | 1901-1913 | |
| 8 | Darío Centeno# | 1.993 | 1902-1915 | |
| 9 | Gabriel Morales# | 2.033 | 1906-1911 | |
| 10 | Telamón Ávila | 2.139 | 1912-1913 | |
| 11 | Jesús Sánchez# | 2.229 | 1906-1914 | |
| 12 | Julio Hernández | 2.231 | 1901-1912 | |
| 13 | Tung Cao# | 2.250 | 1913-1915 | |
| 14 | Efraín Castro | 2.323 | 1901-1911 | |
| 15 | Ross Culp | 2.352 | 1901-1911 | |
| 16 | Manuel Barragán | 2.406 | 1902-1912 | |
| 17 | José Cisneros# | 2.469 | 1902-1913 | |
| 18 | Rhys Wilson | 2.594 | 1906-1914 | |
| 19 | Crisóstomo Yáñez# | 2.630 | 1911-1915 | |
| 20 | Orlando Figueroa# | 2.673 | 1912-1915 | |
| 21 | Oscar Escalante | 2.700 | 1901-1904 | |
| 22 | Catulo Martínez | 2.717 | 1901-1906 | |
| 23 | Noé González | 2.938 | 1901-1911 | |
| 24 | Felipe García | 3.014 | 1903-1913 | |
| 25 | Bonifacio Martínez# | 3.028 | 1911-1915 | |
| 26 | Carlos Caballero | 3.032 | 1903-1912 | |
| 27 | Vicente Valdez | 3.062 | 1901-1906 | |
| 28 | Latif bin Afif# | 3.071 | 1913-1915 | |
| 29 | Felipe Ramos# | 3.087 | 1906-1913 | |
| 30 | Imrich Tosenovsky# | 3.106 | 1913-1915 | |
| 31 | Florián Sandoval# | 3.133 | 1905-1914 | |
| 32 | Édgar González# | 3.135 | 1910-1913 | |
| 33 | Virgilio Felán | 3.158 | 1901-1910 | |
| 34 | Santiago Romero | 3.176 | 1911-1913 | |
| 35 | Matías Martínez# | 3.180 | 1905-1915 | |
| 36 | Pablo Villada | 3.243 | 1902-1913 | |
| 37 | Tibulo Rodríguez# | 3.250 | 1912-1913 | |
| 38 | Timoteo Muriel# | 3.253 | 1905-1913 | |
| 39 | Luis Martínez# | 3.273 | 1906-1909 | |
| 40 | Ramón Pagán | 3.285 | 1902-1913 | |
| 41 | Oscar Soto | 3.287 | 1903-1913 | |
| 42 | Rafael Martínez# | 3.296 | 1910-1915 | |
| 43 | Patricio Rodríguez | 3.303 | 1901-1908 | |
| 44 | Prudencio Ulloa# | 3.375 | 1906-1915 | |
| 45 | Francisco García# | 3.488 | 1905-1913 | |
| 46 | Hugo Medrano# | 3.619 | 1906-1915 | |
| 47 | Judá García# | 3.635 | 1906-1910 | |
| 48 | Jesús Escobales | 3.672 | 1902-1912 | |
| 49 | Egidio Rodríguez | 3.690 | 1901-1914 | |
| 50 | Bartolomé Carrada | 3.710 | 1903-1911 | |
| 51 | Joaquín Espinosa | 3.724 | 1901-1906 | |
| 52 | Carlos Guzmán | 3.797 | 1901-1906 | |
| 53 | Séptimo Salazar# | 3.825 | 1912-1915 | |
| 54 | Elián Lara | 3.827 | 1903-1911 | |
| 55 | Erasmo Pérez | 3.830 | 1901-1906 | |
| 56 | Esteban Baubia# | 3.884 | 1906-1915 | |
| 57 | Marcos Guevara | 3.894 | 1903-1912 | |
| 58 | Søren Fetterlein# | 3.900 | 1912-1914 | |
| 59 | Javier Cortez# | 3.904 | 1906-1909 | |
| 60 | Weston Bourgeois | 3.914 | 1906-1914 | |
| 61 | Osvaldo Rosales# | 3.949 | 1903-1913 | |
| 62 | Cirilo Calderón# | 3.951 | 1911-1911 | |
| 63 | Acacio Tejada | 3.984 | 1901-1911 | |
| 64 | Eppa Rixey# | 4.037 | 1914-1915 | |
| 65 | Mateo Lugo | 4.050 | 1901-1907 | |
| 66 | Octavio Álvarez | 4.071 | 1901-1913 | |
| 67 | Jorge Reyes | 4.117 | 1901-1905 | |
| 68 | Miguel Díaz | 4.139 | 1904-1906 | |
| 69 | Teófilo Espinal# | 4.161 | 1909-1915 | |
| 70 | Adrián Acosta | 4.197 | 1901-1909 | |
| 71 | Jorge Ruiz | 4.238 | 1901-1910 | |
| 72 | Lorenzo Cabrera | 4.273 | 1901-1911 | |
| 73 | Antonio Chatsaga# | 4.311 | 1915-1915 | |
| 74 | Francisco Aguilar# | 4.320 | 1910-1915 | |
| 75 | Pedro Ayala# | 4.334 | 1906-1915 | |
| 76 | Diego Bedolla# | 4.355 | 1905-1909 | |
| 77 | Remigio Vallez# | 4.390 | 1914-1914 | |
| 78 | Julio Morales | 4.412 | 1901-1909 | |
| 79 | Mike Holtzer | 4.418 | 1901-1904 | |
| 80 | Reginaldo Cervantes | 4.436 | 1901-1912 | |
| 81 | Emeterio Torres | 4.455 | 1902-1911 | |
| 82 | Ulises Ramírez | 4.500 | 1901-1911 | |
| 83 | Dalmacio Ramos | 4.588 | 1903-1915 | |
| 84 | Liu-liang Shen# | 4.590 | 1913-1915 | |
| 85 | Adrián Jiménez | 4.651 | 1901-1905 | |
| 86 | Diego Navarro# | 4.655 | 1905-1913 | |
| 87 | Michael Allan | 4.678 | 1904-1911 | |
| 88 | Frank Groves# | 4.686 | 1913-1914 | |
| 89 | Stepán Sindelar# | 4.846 | 1910-1915 | |
| 90 | Símaco Montes | 4.863 | 1901-1913 | |
| 91 | Les Haynes | 4.888 | 1907-1911 | |
| 92 | Ignacio Prado# | 4.896 | 1906-1912 | |
| 93 | Juan Medina# | 5.075 | 1912-1915 | |
| 94 | Juan Padín | 5.121 | 1901-1910 | |
| 95 | Íñigo León# | 5.165 | 1902-1915 | |
| 96 | Gelasio Campos# | 5.173 | 1906-1912 | |
| 97 | Joseph Scott | 5.571 | 1911-1915 | |
| 98 | Eugenio Pérez# | 5.842 | 1906-1911 | |
| 99 | Epifanio Cuenca# | 5.862 | 1903-1915 | |
| 100 | Ángel Flores# | 5.906 | 1907-1909 |
