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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Career Leaderboard |
|---|---|---|---|---|
| 1 | Jorge Delgado | 1.412 | 1905 | |
| 2 | Jorge Delgado | 1.415 | 1904 | |
| 3 | Blas García# | 1.522 | 1905 | |
| 4 | Serafín García# | 1.672 | 1906 | |
| 5 | Albán Yáñez# | 1.678 | 1904 | |
| 6 | Atilano Espinosa# | 1.709 | 1906 | |
| 7 | Gabriel Palacios# | 1.728 | 1909 | |
| 8 | Atilio Enríquez | 1.742 | 1905 | |
| 9 | Héctor Arellano# | 1.751 | 1906 | |
| 9 | Almandeto Castro# | 1.751 | 1905 | |
| 11 | Atilano Espinosa# | 1.794 | 1904 | |
| 11 | Bolívar Carabajal# | 1.794 | 1904 | |
| 13 | Sebastián Morillo | 1.800 | 1906 | |
| 14 | Blas García# | 1.812 | 1907 | |
| 15 | Jorge Delgado | 1.821 | 1906 | |
| 16 | Fernando Cuestas# | 1.831 | 1905 | |
| 17 | Albán Yáñez# | 1.832 | 1906 | |
| 18 | Álvaro López | 1.841 | 1904 | |
| 18 | Almandeto Castro# | 1.841 | 1906 | |
| 20 | Pedro Marrón# | 1.908 | 1903 | |
| 21 | Augurio Marín# | 1.926 | 1906 | |
| 22 | Salustiano Contreras# | 1.939 | 1905 | |
| 23 | Jacinto Soto# | 1.960 | 1905 | |
| 24 | Salustiano Contreras# | 1.971 | 1904 | |
| 25 | Toad Ramsey | 1.984 | 1904 | |
| 26 | Atilano Espinosa# | 1.996 | 1905 | |
| 27 | Roodan Wilson# | 1.999 | 1905 | |
| 28 | Álvaro Piña | 2.005 | 1904 | |
| 29 | José Ocampo# | 2.016 | 1906 | |
| 30 | Calvino Garza | 2.033 | 1906 | |
| 31 | José Ocampo# | 2.043 | 1904 | |
| 32 | Pedro Santiago | 2.045 | 1906 | |
| 33 | Callum Ferguson# | 2.051 | 1906 | |
| 34 | Héctor Arellano# | 2.054 | 1908 | |
| 35 | José Ocampo# | 2.057 | 1903 | |
| 36 | Bonifacio Coronado# | 2.058 | 1905 | |
| 37 | Julio Cantú | 2.072 | 1905 | |
| 38 | Álvaro López | 2.073 | 1905 | |
| 39 | Blas García# | 2.075 | 1908 | |
| 40 | Calvino Garza | 2.077 | 1905 | |
| 41 | Ramiro López# | 2.098 | 1905 | |
| 42 | Bernardo Carrillo# | 2.099 | 1905 | |
| 43 | Albán Yáñez# | 2.100 | 1905 | |
| 44 | Ernesto Jiménez# | 2.106 | 1905 | |
| 45 | José Borges# | 2.108 | 1913 | |
| 46 | Elton Porter# | 2.111 | 1906 | |
| 46 | Isaac Castro# | 2.111 | 1905 | |
| 48 | Pedro Marrón# | 2.115 | 1911 | |
| 49 | Augurio Marín# | 2.118 | 1907 | |
| 50 | Juan María Hernández# | 2.133 | 1905 | |
| 51 | Almandeto Castro# | 2.141 | 1904 | |
| 51 | Calvino Mejía# | 2.141 | 1910 | |
| 53 | Miguel Castañeda# | 2.146 | 1906 | |
| 54 | Atilano Espinosa# | 2.153 | 1907 | |
| 55 | Apolodoro Preciado | 2.167 | 1904 | |
| 55 | Julio Estrada# | 2.167 | 1906 | |
| 55 | Octavio Morales# | 2.167 | 1913 | |
| 58 | Jorge Delgado | 2.181 | 1903 | |
| 59 | Calvino Mejía# | 2.195 | 1907 | |
| 60 | Héctor Arellano# | 2.205 | 1910 | |
| 61 | Lorenzo Flores | 2.219 | 1904 | |
| 62 | Jim Devlin | 2.224 | 1905 | |
| 63 | Dominique Dumoulin# | 2.231 | 1907 | |
| 64 | Homero Iglesias | 2.234 | 1904 | |
| 65 | Luis Orozco | 2.237 | 1905 | |
| 66 | Arnulfo Muñoz# | 2.239 | 1908 | |
| 67 | Chase Lyons | 2.240 | 1904 | |
| 68 | Armando Cabañas# | 2.245 | 1907 | |
| 69 | Calvino Garza | 2.247 | 1904 | |
| 70 | Jacinto Soto# | 2.248 | 1906 | |
| 71 | Roodan Wilson# | 2.255 | 1904 | |
| 71 | Justino Rivera | 2.255 | 1906 | |
| 73 | José Muñoz# | 2.260 | 1904 | |
| 74 | Blas García# | 2.264 | 1906 | |
| 75 | Justino Rivera | 2.268 | 1905 | |
| 76 | Atilano Espinosa# | 2.269 | 1910 | |
| 77 | Gabriel Palacios# | 2.270 | 1906 | |
| 78 | Gabriel García# | 2.280 | 1912 | |
| 79 | Cristóbal Pérez# | 2.291 | 1905 | |
| 80 | Joe Yeager# | 2.292 | 1904 | |
| 80 | Donato Rodríguez | 2.292 | 1904 | |
| 82 | Atilio Enríquez | 2.295 | 1906 | |
| 83 | Sebastián Morillo | 2.307 | 1904 | |
| 84 | Jacinto Soto# | 2.311 | 1904 | |
| 85 | Radamés Bueno | 2.313 | 1905 | |
| 86 | Esteban Prats | 2.314 | 1906 | |
| 87 | Atilio Enríquez | 2.316 | 1904 | |
| 87 | Justino Rivera | 2.316 | 1904 | |
| 87 | Armando Cabañas# | 2.316 | 1906 | |
| 87 | José Rodríguez# | 2.316 | 1905 | |
| 91 | Calvino Mejía# | 2.337 | 1904 | |
| 92 | Bolívar Carabajal# | 2.338 | 1905 | |
| 93 | Gabriel Salinas# | 2.342 | 1904 | |
| 94 | Salvador Luna# | 2.345 | 1913 | |
| 95 | Armando Cabañas# | 2.352 | 1904 | |
| 96 | Ordoño Hernández# | 2.357 | 1906 | |
| 97 | Álvaro Piña | 2.362 | 1908 | |
| 98 | William Bell# | 2.366 | 1905 | |
| 99 | William Bell# | 2.367 | 1904 | |
| 100 | Álvaro Piña | 2.368 | 1905 |
