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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gumersindo Saavedra | 1903-1913 | 23 | 44 | .343 | 4.99 | 205 | 65 | 15 | 0 | 4 | 842.2 | 906 | 467 | 50 | 616 | 408 |
| Filóxenos Salazar | 1904-1914 | 23 | 9 | .719 | 3.70 | 146 | 4 | 3 | 0 | 12 | 394.0 | 433 | 162 | 15 | 134 | 96 |
| Julio César Salazar | 1903-1903 | 12 | 12 | .500 | 4.22 | 29 | 24 | 18 | 2 | 0 | 217.1 | 264 | 102 | 14 | 54 | 34 |
| Sílvano Salguero | 1903-1911 | 30 | 34 | .469 | 2.87 | 124 | 44 | 26 | 3 | 10 | 524.0 | 498 | 167 | 23 | 138 | 258 |
| Gabriel Salinas | 1903-1914 | 109 | 145 | .429 | 3.82 | 341 | 279 | 137 | 25 | 4 | 2324.2 | 2153 | 986 | 85 | 1354 | 1302 |
| Eduardo Sandoval | 1907-1914 | 51 | 60 | .459 | 3.17 | 235 | 85 | 30 | 4 | 34 | 913.1 | 747 | 322 | 26 | 485 | 706 |
| Mario Santa Ana | 1910-1914 | 66 | 79 | .455 | 3.27 | 224 | 153 | 53 | 8 | 17 | 1345.0 | 1296 | 489 | 32 | 558 | 696 |
| Gustavo Santana | 1906-1914 | 103 | 158 | .395 | 4.14 | 371 | 315 | 86 | 14 | 2 | 2359.0 | 2276 | 1084 | 97 | 1366 | 1258 |
| Miguel Santiago | 1907-1914 | 48 | 27 | .640 | 2.58 | 307 | 0 | 0 | 0 | 96 | 488.0 | 447 | 140 | 14 | 135 | 398 |
| Pedro Santiago | 1903-1911 | 99 | 81 | .550 | 2.92 | 287 | 162 | 91 | 19 | 28 | 1568.0 | 1378 | 509 | 67 | 503 | 972 |
| Cicerón Sepeda | 1909-1914 | 39 | 52 | .429 | 3.49 | 133 | 116 | 29 | 5 | 0 | 852.0 | 809 | 330 | 20 | 392 | 541 |
| George Sharrott | 1903-1904 | 12 | 5 | .706 | 2.99 | 27 | 20 | 13 | 3 | 0 | 183.2 | 192 | 61 | 11 | 94 | 64 |
| C. Smith | 1903-1910 | 22 | 24 | .478 | 3.37 | 153 | 0 | 0 | 0 | 22 | 283.0 | 294 | 106 | 21 | 59 | 183 |
| C. Smith | 1903-1914 | 100 | 99 | .503 | 3.44 | 330 | 163 | 89 | 9 | 45 | 1558.1 | 1510 | 595 | 75 | 410 | 1186 |
| Gilberto Solís | 1907-1914 | 9 | 2 | .818 | 6.19 | 49 | 0 | 0 | 0 | 6 | 75.2 | 102 | 52 | 3 | 52 | 53 |
| Andy Sommerville | 1903-1906 | 1 | 2 | .333 | 5.27 | 9 | 0 | 0 | 0 | 0 | 13.2 | 14 | 8 | 1 | 9 | 8 |
| Jacinto Soto | 1903-1914 | 181 | 171 | .514 | 3.18 | 390 | 378 | 270 | 38 | 5 | 3222.1 | 3215 | 1140 | 122 | 704 | 1983 |
| Charlie Sprague | 1904-1907 | 6 | 9 | .400 | 3.62 | 35 | 17 | 14 | 2 | 0 | 189.0 | 204 | 76 | 10 | 65 | 86 |
| Scott Stratton | 1903-1903 | 22 | 9 | .710 | 2.87 | 32 | 32 | 28 | 4 | 0 | 276.1 | 306 | 88 | 10 | 50 | 144 |
| Bernal Sánchez | 1903-1903 | 8 | 3 | .727 | 2.93 | 26 | 10 | 7 | 3 | 2 | 107.2 | 107 | 35 | 3 | 28 | 40 |
| Gonzalo Sánchez | 1904-1914 | 10 | 8 | .556 | 2.97 | 95 | 0 | 0 | 0 | 6 | 173.0 | 181 | 57 | 14 | 51 | 114 |
| Mateo Sánchez | 1903-1905 | 2 | 7 | .222 | 4.81 | 44 | 9 | 0 | 0 | 0 | 138.1 | 143 | 74 | 22 | 46 | 71 |
