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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Player | From-To | W | L | Pct | ERA | G | GS | CG | SHO | SV | IP | H | ER | HR | BB | SO |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gabriel Saavedra | 1908-1908 | 5 | 6 | .455 | 3.86 | 14 | 12 | 4 | 1 | 0 | 95.2 | 93 | 41 | 0 | 25 | 7 |
| Pedro Saiz | 1906-1915 | 42 | 45 | .483 | 3.64 | 143 | 94 | 48 | 7 | 1 | 765.2 | 817 | 310 | 1 | 216 | 131 |
| Carlos Salas | 1906-1906 | 0 | 2 | .000 | 3.32 | 3 | 3 | 1 | 0 | 0 | 19.0 | 14 | 7 | 0 | 14 | 2 |
| Ramón Salas | 1906-1915 | 17 | 24 | .415 | 4.70 | 160 | 21 | 1 | 0 | 17 | 369.2 | 414 | 193 | 0 | 221 | 92 |
| Baltasar Saldaña | 1907-1909 | 23 | 22 | .511 | 3.61 | 54 | 50 | 24 | 4 | 1 | 398.2 | 441 | 160 | 2 | 103 | 65 |
| Martín Saldaña | 1910-1915 | 24 | 17 | .585 | 2.02 | 197 | 0 | 0 | 0 | 63 | 263.0 | 250 | 59 | 1 | 44 | 47 |
| Nehemías Sandoval | 1906-1915 | 56 | 86 | .394 | 4.54 | 258 | 150 | 28 | 5 | 3 | 1232.1 | 1441 | 621 | 4 | 621 | 253 |
| Diego Santiago | 1909-1911 | 1 | 2 | .333 | 7.17 | 8 | 2 | 0 | 0 | 0 | 21.1 | 39 | 17 | 0 | 6 | 3 |
| Raúl Santiago | 1908-1915 | 47 | 33 | .588 | 4.09 | 140 | 80 | 21 | 3 | 2 | 717.2 | 785 | 326 | 1 | 238 | 144 |
| Baldovino Santillán | 1906-1915 | 146 | 137 | .516 | 3.63 | 353 | 314 | 151 | 15 | 2 | 2551.1 | 2832 | 1029 | 2 | 598 | 393 |
| Ricardo Seda | 1906-1907 | 0 | 5 | .000 | 5.26 | 21 | 0 | 0 | 0 | 1 | 25.2 | 43 | 15 | 0 | 7 | 9 |
| Hércules Serafín | 1909-1915 | 21 | 22 | .488 | 3.78 | 98 | 48 | 11 | 4 | 3 | 455.0 | 527 | 191 | 3 | 141 | 62 |
| José Shaefer | 1907-1915 | 92 | 84 | .523 | 3.87 | 250 | 213 | 79 | 6 | 1 | 1641.1 | 1816 | 705 | 0 | 468 | 263 |
| Euan Sharp | 1906-1915 | 60 | 94 | .390 | 4.23 | 199 | 175 | 69 | 9 | 2 | 1387.0 | 1597 | 652 | 3 | 429 | 224 |
| José Silva | 1910-1910 | 1 | 3 | .250 | 4.46 | 7 | 6 | 0 | 0 | 0 | 38.1 | 37 | 19 | 0 | 30 | 8 |
| Pero Sogliano | 1906-1915 | 135 | 139 | .493 | 3.48 | 338 | 321 | 157 | 33 | 2 | 2582.1 | 2796 | 998 | 4 | 571 | 437 |
| Heraclio Solorio | 1910-1915 | 14 | 20 | .412 | 3.83 | 172 | 0 | 0 | 0 | 11 | 249.0 | 263 | 106 | 0 | 109 | 89 |
| Gerardo Solís | 1906-1912 | 64 | 74 | .464 | 3.80 | 192 | 156 | 69 | 7 | 3 | 1275.0 | 1434 | 539 | 3 | 283 | 260 |
| Celedonio Soto | 1912-1912 | 3 | 2 | .600 | 6.81 | 28 | 0 | 0 | 0 | 5 | 38.1 | 65 | 29 | 0 | 13 | 9 |
| Carmelo Sánchez | 1906-1906 | 1 | 1 | .500 | 2.25 | 9 | 0 | 0 | 0 | 0 | 8.0 | 12 | 2 | 0 | 3 | 2 |
| Juan Sánchez | 1915-1915 | 8 | 15 | .348 | 3.78 | 34 | 32 | 3 | 0 | 0 | 221.1 | 239 | 93 | 0 | 90 | 31 |
