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| League History Index | Players | Teams | Managers | Leagues | Leaderboards | Awards | Accomplishments |
| Rank | Player | ERA | YEAR | Open Season Leaderboard |
|---|---|---|---|---|
| 1 | Fulgencio Meraz | 2.417 | 1901-1905 | |
| 2 | Napoleón Peña# | 2.494 | 1905-1913 | |
| 3 | Guadalupe Macías# | 2.599 | 1904-1913 | |
| 4 | Rory Beveridge# | 2.655 | 1905-1912 | |
| 5 | Tarasio Martínez# | 2.681 | 1906-1913 | |
| 6 | Gary Tobias# | 2.685 | 1911-1913 | |
| 7 | Serafín Villanueva# | 2.717 | 1905-1909 | |
| 8 | Jean-Claude Pinault | 2.755 | 1904-1905 | |
| 9 | Carmelo Ramírez# | 2.788 | 1905-1913 | |
| 10 | Narciso Armendáriz# | 2.946 | 1905-1910 | |
| 11 | Fernando Chávez# | 2.962 | 1903-1910 | |
| 12 | Poncio Gamero# | 2.976 | 1911-1913 | |
| 13 | Fidel Paredes# | 2.979 | 1905-1911 | |
| 14 | Tirso de la Rosa | 3.009 | 1901-1906 | |
| 15 | Roberto Zúñiga# | 3.023 | 1904-1913 | |
| 16 | William Noble# | 3.050 | 1907-1913 | |
| 17 | Eneas Cantú | 3.056 | 1901-1904 | |
| 18 | Félix Castillo | 3.060 | 1901-1904 | |
| 19 | Marco Antonio Santana# | 3.061 | 1905-1913 | |
| 20 | Catulo González | 3.063 | 1905-1910 | |
| 21 | Jacinto Chávez | 3.083 | 1901-1905 | |
| 22 | Vicente Castro# | 3.102 | 1911-1913 | |
| 23 | Jesús García | 3.107 | 1901-1910 | |
| 24 | Juan Santos# | 3.128 | 1906-1913 | |
| 25 | Viriato Rodríguez# | 3.135 | 1905-1911 | |
| 26 | Bernal Lupercio | 3.149 | 1901-1910 | |
| 27 | Goliat Portillo | 3.155 | 1901-1910 | |
| 28 | Isidoro Núñez# | 3.163 | 1906-1912 | |
| 29 | Álvar Ramírez | 3.164 | 1901-1909 | |
| 30 | David Rodríguez | 3.208 | 1901-1910 | |
| 31 | Emanuel González# | 3.209 | 1905-1912 | |
| 32 | Norberto Luján | 3.225 | 1901-1905 | |
| 33 | Saturnín Juárez# | 3.230 | 1901-1910 | |
| 34 | Sófocles Rodríguez | 3.247 | 1902-1906 | |
| 35 | Enrique Ruiz | 3.262 | 1904-1906 | |
| 36 | Julián Rodríguez | 3.265 | 1905-1906 | |
| 37 | Arnulfo Sánchez# | 3.272 | 1903-1910 | |
| 38 | Ángel Rivera# | 3.315 | 1903-1913 | |
| 39 | Luis Sanabria# | 3.330 | 1909-1913 | |
| 40 | Cole Farrell | 3.368 | 1901-1905 | |
| 41 | Orlando Vaca# | 3.395 | 1909-1912 | |
| 42 | Evan Brooks# | 3.403 | 1907-1910 | |
| 43 | Felipe Duarte# | 3.435 | 1902-1910 | |
| 44 | Onur Yamak# | 3.447 | 1911-1913 | |
| 45 | Gabriel Benites# | 3.449 | 1905-1910 | |
| 46 | Roberto Rosado | 3.458 | 1902-1913 | |
| 47 | Matías Silva | 3.466 | 1901-1906 | |
| 48 | Marco González# | 3.474 | 1905-1912 | |
| 49 | Adrián Bobadilla# | 3.541 | 1911-1913 | |
| 50 | Víctor Manuel Huerta | 3.545 | 1901-1905 | |
| 51 | Ralph Caldwell | 3.578 | 1904-1913 | |
| 52 | Jaime Ramírez | 3.606 | 1904-1912 | |
| 53 | Gabriel Ibarra | 3.634 | 1901-1906 | |
| 54 | Jim Cole | 3.635 | 1901-1910 | |
| 55 | Elías Martínez# | 3.651 | 1911-1913 | |
| 56 | Juan Cervantes | 3.665 | 1902-1911 | |
| 56 | Juan Robles | 3.665 | 1901-1903 | |
| 58 | Dougalasa Kolet# | 3.679 | 1912-1913 | |
| 59 | Pirro Arias# | 3.702 | 1905-1910 | |
| 60 | Emanuel Zambrano | 3.705 | 1902-1907 | |
| 61 | Casimiro Castro# | 3.708 | 1911-1913 | |
| 62 | Eumeo Hernández | 3.711 | 1908-1913 | |
| 63 | Honorio Reyes# | 3.718 | 1908-1912 | |
| 64 | Álvar Nieves | 3.719 | 1901-1906 | |
| 65 | Roberto Sojo | 3.732 | 1904-1909 | |
| 66 | Ismael Sandoval | 3.735 | 1901-1905 | |
| 66 | Germán Sibaja | 3.735 | 1901-1909 | |
| 68 | Mateo Sánchez | 3.736 | 1901-1905 | |
| 69 | Aristodemo González | 3.766 | 1901-1905 | |
| 70 | Clarkin O'Connell | 3.787 | 1906-1910 | |
| 71 | Isidoro Fernández# | 3.804 | 1905-1913 | |
| 72 | Miguel Venegas | 3.810 | 1902-1909 | |
| 73 | Adrián López# | 3.838 | 1906-1913 | |
| 74 | Calvino Carpio# | 3.863 | 1904-1912 | |
| 75 | Miguel Ángel Garza | 3.867 | 1903-1912 | |
| 76 | Manuel Herrera | 3.884 | 1907-1913 | |
| 77 | Leoncio Gallegos# | 3.886 | 1910-1913 | |
| 78 | Ernesto Altamirano | 3.927 | 1901-1909 | |
| 79 | Efraín López# | 3.933 | 1910-1913 | |
| 80 | Miqueas Álvarez | 3.946 | 1901-1907 | |
| 81 | Newt Turnbull | 4.006 | 1906-1912 | |
| 82 | Raúl Ulibarri# | 4.037 | 1911-1913 | |
| 83 | Matías Piñeda | 4.072 | 1901-1904 | |
| 84 | Tomás Jaimes | 4.093 | 1901-1904 | |
| 85 | Édgar Martínez | 4.105 | 1904-1912 | |
| 86 | Saturnín Hernández# | 4.119 | 1911-1913 | |
| 87 | Rick Jerome# | 4.123 | 1904-1912 | |
| 88 | Jayden Trueman | 4.124 | 1901-1908 | |
| 89 | Tiburcio Estrada | 4.130 | 1901-1906 | |
| 90 | Anaximandro Gardea | 4.133 | 1901-1911 | |
| 91 | Adolfo García | 4.135 | 1904-1910 | |
| 92 | Rodolfo Valdés# | 4.140 | 1907-1912 | |
| 93 | Jesús Becerra | 4.194 | 1901-1909 | |
| 94 | Buenaventura Parrales# | 4.263 | 1909-1912 | |
| 95 | Daniel Báez | 4.292 | 1901-1905 | |
| 96 | Ricardo González# | 4.363 | 1902-1905 | |
| 97 | Efraín Sainz | 4.506 | 1905-1911 | |
| 98 | Adán Ledezma | 4.515 | 1901-1904 | |
| 99 | Arnaldo Cintrón | 4.653 | 1901-1909 | |
| 100 | Rick O'Brien# | 4.896 | 1907-1912 |
